[[(1S,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl]-phenylphosphoryl]benzene profile

Cross-References

ID Source	ID
PubMed CID	21678144
CHEMBL ID	1088844
CHEBI ID	93748

Synonyms (42)

Synonym
HMS3269O11
BRD-K99922388-001-01-2
NCGC00186012-01
bdbm50315563
{[(1s,2s,5r)-5-methyl-2-(propan-2-yl)cyclohexyl](phenyl)phosphoryl}benzene
CHEMBL1088844 ,
HMS3261N07
dpo-1
(+)-neomenthyl diphenylphosphine oxide
43077-30-1
LP00543
CCG-221847
NCGC00261228-01
tox21_500543
[1s-(1?,2?,5?)]-[5-methyl-2-(1-methylethyl)cyclohexyl]diphenylphosphine oxide
diphenyl phosphine oxide-1
neomenthyldiphenylphosphine oxide
[(1s,2s,5r)-2-isopropyl-5-methylcyclohexyl](diphenyl)phosphine oxide
BPCNGVCAHAIZEE-COPCDDAFSA-N
AKOS024457152
DTXSID10616838
CHEBI:93748
dpo-1, needles, >97% (nmr)
dpo1
gtpl11207
[[(1s,2s,5r)-5-methyl-2-propan-2-ylcyclohexyl]-phenylphosphoryl]benzene
Q27165442
((1s,2s,5r)-2-isopropyl-5-methylcyclohexyl)diphenylphosphine oxide
HMS3677F13
HMS3413F13
SDCCGSBI-0633727.P001
NCGC00186012-04
dpo 1
[1s-(1alpha,2alpha,5beta)]-[5-methyl-2-(1-methylethyl)cyclohexyl]diphenylphosphine oxide
h9lqp293gk ,
phosphine oxide, (5-methyl-2-(1-methylethyl)cyclohexyl)diphenyl-, (1s-(1alpha,2alpha,5beta))-
phosphine oxide, ((1s,2s,5r)-5-methyl-2-(1-methylethyl)cyclohexyl)diphenyl-
(((1s,2s,5r)-5-methyl-2-propan-2-ylcyclohexyl)-phenylphosphoryl)benzene
unii-h9lqp293gk
phosphine oxide, (5-methyl-2-(1-methylethyl)cyclohexyl)diphenyl-, (1s-(1.alpha.,2.alpha.,5.beta.))-
CS-0020060
HY-100712

Class	Description
monoterpenoid	Any terpenoid derived from a monoterpene. The term includes compounds in which the C10 skeleton of the parent monoterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
arylsulfatase A	Homo sapiens (human)	Potency	0.2685	1.0691	13.9551	37.9330	AID720538
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	8.9125	0.0355	20.9770	89.1251	AID504332
chromobox protein homolog 1	Homo sapiens (human)	Potency	0.0047	0.0060	26.1688	89.1251	AID488953
flap endonuclease 1	Homo sapiens (human)	Potency	8.4368	0.1337	25.4129	89.1251	AID588795
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)	IC50 (µMol)	0.2650	0.0300	3.7300	9.0000	AID476474; AID692804
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
potassium ion transport	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
response to hypoxia	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
Notch signaling pathway	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
response to mechanical stimulus	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
response to organic substance	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
regulation of vasoconstriction	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
regulation of membrane potential	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
response to hydrogen peroxide	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
regulation of potassium ion transport	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
regulation of insulin secretion	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
protein homooligomerization	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
negative regulation of cytosolic calcium ion concentration	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
potassium ion homeostasis	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
response to hyperoxia	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
membrane hyperpolarization	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
regulation of atrial cardiac muscle cell membrane repolarization	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
potassium ion transmembrane transport	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
atrial cardiac muscle cell action potential	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
membrane repolarization during bundle of His cell action potential	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
membrane repolarization during SA node cell action potential	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
regulation of heart rate by cardiac conduction	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
potassium ion export across plasma membrane	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
membrane repolarization during atrial cardiac muscle cell action potential	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
positive regulation of G1/S transition of mitotic cell cycle	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
positive regulation of myoblast proliferation	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
action potential	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
signaling receptor binding	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
delayed rectifier potassium channel activity	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
protein binding	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
outward rectifier potassium channel activity	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
protein kinase binding	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
alpha-actinin binding	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
voltage-gated potassium channel activity involved in SA node cell action potential repolarization	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
scaffold protein binding	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
caveola	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
Golgi apparatus	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
plasma membrane	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
cell surface	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
intercalated disc	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
Z disc	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
membrane raft	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
intracellular canaliculus	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
perinuclear region of cytoplasm	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
voltage-gated potassium channel complex	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
potassium channel complex	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
intercalated disc	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
membrane	Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (24)

Assay ID	Title	Year	Journal	Article
AID588349	qHTS for Inhibitors of ATXN expression: Validation of Cytotoxic Assay
AID588378	qHTS for Inhibitors of ATXN expression: Validation
AID1347410	qHTS for inhibitors of adenylyl cyclases using a fission yeast platform: a pilot screen against the NCATS LOPAC library	2019	Cellular signalling, 08, Volume: 60	A fission yeast platform for heterologous expression of mammalian adenylyl cyclases and high throughput screening.
AID1347045	Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot counterscreen GloSensor control cell line	2019	Science translational medicine, 07-10, Volume: 11, Issue:500	Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
AID504810	Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID504812	Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1347151	Optimization of GU AMC qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1508630	Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay	2021	Cell reports, 04-27, Volume: 35, Issue:4	A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1347405	qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS LOPAC collection	2020	ACS chemical biology, 07-17, Volume: 15, Issue:7	High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
AID1347086	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347050	Natriuretic polypeptide receptor (hNpr2) antagonism - Pilot subtype selectivity assay	2019	Science translational medicine, 07-10, Volume: 11, Issue:500	Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
AID1347083	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID504836	Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in human glioma: Validation	2002	The Journal of biological chemistry, Apr-19, Volume: 277, Issue:16	Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
AID1347082	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347049	Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot screen	2019	Science translational medicine, 07-10, Volume: 11, Issue:500	Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
AID1347057	CD47-SIRPalpha protein protein interaction - LANCE assay qHTS validation	2019	PloS one, , Volume: 14, Issue:7	Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors.
AID1347058	CD47-SIRPalpha protein protein interaction - HTRF assay qHTS validation	2019	PloS one, , Volume: 14, Issue:7	Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors.
AID1347059	CD47-SIRPalpha protein protein interaction - Alpha assay qHTS validation	2019	PloS one, , Volume: 14, Issue:7	Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors.
AID1794808	Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).	2014	Journal of biomolecular screening, Jul, Volume: 19, Issue:6	A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808	Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
AID724063	Lipophilicity, log D of compound at pH 7.4	2013	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 23, Issue:3	Synthesis and evaluation of diphenylphosphinic amides and diphenylphosphine oxides as inhibitors of Kv1.5.
AID692806	Octanol-water distribution coefficient, log D of the compound at pH 7.4 by shake-flask method	2012	ACS medicinal chemistry letters, Sep-13, Volume: 3, Issue:9	Symmetric kv1.5 blockers discovered by focused screening.
AID692804	Inhibition of human Kv1.5 ion channel after 3 mins by high-throughput planar patch clamp assay	2012	ACS medicinal chemistry letters, Sep-13, Volume: 3, Issue:9	Symmetric kv1.5 blockers discovered by focused screening.
AID476474	Inhibition of human Kv1.5 channel expressed in CHO cells by whole cell patch clamp assay	2010	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 20, Issue:8	Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (6.67)	29.6817
2010's	8 (53.33)	24.3611
2020's	6 (40.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	15 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
2-amino-1,2-diphenylethanol 2-amino-1,2-diphenylethanol: structure in first source	2.07	1	0

Condition	Relationship Strength	Studies
Plasmodium falciparum Malaria [description not available]	2.1	1
Malaria, Falciparum Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.	2.1	1
Contact Dermatitis [description not available]	2.21	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.63	2
Itching [description not available]	2.21	1
Dermatitis, Contact A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.	2.21	1
Pruritus An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.	2.21	1
Congenital Zika Syndrome [description not available]	2.25	1
Zika Virus Infection A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.	2.25	1

[[(1S,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl]-phenylphosphoryl]benzene

Cross-References

Synonyms (42)

Drug Classes (1)

Protein Targets (5)

Potency Measurements

Inhibition Measurements

Biological Processes (26)

Molecular Functions (10)

Ceullar Components (12)

Bioassays (24)

Research

Studies (15)

Market Indicators

Research Demand Index: 12.17

Study Types

[[(1S,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl]-phenylphosphoryl]benzene

Cross-References

Synonyms (42)

Drug Classes (1)

Protein Targets (5)

Potency Measurements

Inhibition Measurements

Biological Processes (26)

Molecular Functions (10)

Ceullar Components (12)

Bioassays (24)

Research

Studies (15)

Market Indicators

Research Demand Index: 12.17

Study Types

Related Drugs (1)

Related Conditions (9)